New from @vmetzis.bsky.social & co Vagal & trunk neural crest cells share transient epiblast origin, but temporal regionalisation preconfigures their identity before crest induction Cdx1 acts before Cdx2, setting distinct chromatin and HOX state in the epiblast www.biorxiv.org/content/10.6...
Temporally distinct CDX programmes preconfigure vagal and trunk neural crestNeural crest cells (NCCs) are progenitor cells vital in establishing the head, heart, gut and peripheral nervous system of vertebrate embryos. Disruptions to NCC development underlie neurocristopathie...www.biorxiv.org