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It's not often single author primary research papers are published in our field & it's even rarer when the author is a Nobel Prize winner Check out the new work by Eric Wieschaus in @dev-journal.bsky.social Flattening maternal gradients in Drosophila embryo journals.biologists.com/dev/article/...

Maternal patterning in early Drosophila embryos: how much information can single maternal gradients supply?Highlighted Article: Comparison of the patterning capacity of Drosophila embryos that have only one of the three maternal gradients known to control anterior posterior patterning.journals.biologists.com

New from @vmetzis.bsky.social & co Vagal & trunk neural crest cells share transient epiblast origin, but temporal regionalisation preconfigures their identity before crest induction Cdx1 acts before Cdx2, setting distinct chromatin and HOX state in the epiblast www.biorxiv.org/content/10.6...

Temporally distinct CDX programmes preconfigure vagal and trunk neural crestNeural crest cells (NCCs) are progenitor cells vital in establishing the head, heart, gut and peripheral nervous system of vertebrate embryos. Disruptions to NCC development underlie neurocristopathie...www.biorxiv.org

Five toed chicken anyone? Nice work from @matt-towers.bsky.social & co on reconstructing the evolutionary pathway to digit loss in birds

Paying peer reviewers Interview with @danielgorelick.bsky.social about @biologyopen.bsky.social Fast & Fair trial in which peer reviewers were paid £220/review Spoiler: it works - fast, high quality reviews www.nature.com/articles/d41...

Why paying peer reviewers works, according to a journal’s editor-in-chiefA biology journal that paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.www.nature.com

New in @dev-journal.bsky.social: how tissue shape tells cells what to become Using human stem-cell neuruloids, we show how that physical boundaries encode positional information that drives cell fate patterning in a model of trunk formation A thread 🧵 journals.biologists.com/dev/article/...

Boundary constraints can determine pattern emergenceSummary: A reaction-diffusion mechanism recapitulates pattern emergence in an in vitro model of neuromesodermal progenitors under a variety of boundary and geometrical perturbations.journals.biologists.com

In our latest editorial @amjeve.uk & I take on the dreaded impact factor Like Monday mornings no one likes them but you can't ignore them & they keep coming around However there are things we should all do as authors, reviewers & editors journals.biologists.com/dev/article/...

The elephant in the room: impact factorSummary: This Editorial offers an honest look at impact factor trends in developmental biology, explains how Development serves its community, and makes the case that sustaining developmental biology ...journals.biologists.com

As Editor of @dev-journal.bsky.social I get asked "What are you doing about your impact factor?" In our new editorial we say: Ask not what Dev can do for the impact factor. Ask what you can do for Dev's IF The IF is about how we all cite, review & assess each other's work doi.org/10.1242/dev....

The elephant in the room: impact factorSummary: This Editorial offers an honest look at impact factor trends in developmental biology, explains how Development serves its community, and makes the case that sustaining developmental biology ...doi.org

New Review: The notochord From transient embryonic source of morphogen for patterning the neural tube and somites to the cells that persist in intervertebral discs We bring together development, single-cell data and stem cell models of notochord formationn journals.biologists.com/dev/article/...

The notochord: development, disease and stem cell-based modellingSummary: This Review discusses how developmental and stem cell studies of the notochord can reveal key insights into spine formation and intervertebral disc development and maintenance, providing new ...journals.biologists.com

Our latest: Minimal essential requirements for neural tube self-organisation How does a single cell give rise to a tissue with the right cell types in the right proportions? We deconstruct and rebuild a self-organising tissue from first principles A thread🧵 www.biorxiv.org/content/10.6...

Minimal essential requirements for neural tube self-organisationThe reliable generation of diverse cell types in precise proportions is essential for the formation of functional tissues during embryonic development. Three-dimensional organoid models derived from p...www.biorxiv.org

Is this the future of peer review? New from @biologyopen.bsky.social: expanded Fast & Fair trial paying reviewers £220 per paper The result: rapid peer review with no drop in quality or change in acceptance rate Paying referees makes peer review faster & fairer www.biorxiv.org/content/10.6...

Looks like the 2027 Dev Bio GRC is shaping up to be another good one: www.grc.org/developmenta...

Congratulations to my wonderful @crick.ac.uk colleagues Michael Way FRS and Jean Langhorne FRS on election to the @royalsociety.org

Many thanks to @mads100tist.bsky.social for hosting me. I had a great day visiting @biozentrum.unibas.ch

Looking forward to a day at the Biozentrum, Basel Seminar at 12.15

A generally sensible and pragmatic report on ethics of neural organoids from @nuffieldbioethics.bsky.social Good to see recognised that there's more to the field than "mini-brains" Serious work now needed to develop guidelines/regulation appropriate for the diversity of neural organoids & uses